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Low crosstalk switch unit for dense piezoelectric sensor networks

Lei QIU, Shenfang YUAN,

《机械工程前沿（英文）》 2009年第4卷第4期页码 401-406 doi: 10.1007/s11465-009-0047-4

摘要： Structural health monitoring (SHM), on the basis of piezoelectric (PZT) sensors and lamb wave method, is efficient in estimating the state of monitored structures. Furthermore, to monitor large-scale structures, dense piezoelectric sensor networks are required, which usually contain many piezoelectric sensor pairs called actuator-sensor channels. In that case, considering the few data acquisition channels especially in the data acquisition board with a high sampling rate and limited quantity of signal amplifiers used in an integrated computer system, a switch unit is adopted to switch to different channels. Because of the high frequency and power of the lamb wave excitation signal, there exists a crosstalk signal in the switch unit. A large crosstalk signal is mixed into the response signal so that the on/off-line signal processing task is difficult to achieve. This paper first analyzes the crosstalk signal phenomenon, describes its production mechanism, and proposes a method to reduce it. Then a 24-switch channel low crosstalk switch unit based on a digital I/O board PCI7248 produced by Adlink technology is developed. An experiment is implemented to validate it. Its low crosstalk characteristics make it promote the real application of the SHM based active lamb wave method. Finally, a general software program based on LabVIEW software platform is developed to control this switch unit.

关键词： structural health monitoring (SHM) piezoelectric (PZT) sensor networks switch unit crosstalk signal

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Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between

《医学前沿（英文）》 2023年第17卷第3期页码 549-561 doi: 10.1007/s11684-022-0965-7

摘要： Immunoglobulin (IgG) glycosylation affects the effector functions of IgG in a myriad of biological processes and has been closely associated with numerous autoimmune diseases, including systemic lupus erythematosus (SLE), thus underlining the pathogenic role of glycosylation aberration in autoimmunity. This study aims to explore the relationship between IgG sialylation patterns and lupus pregnancy. Relative to that in serum samples from the control cohort, IgG sialylation level was aberrantly downregulated in serum samples from the SLE cohort at four stages (from preconception to the third trimester of pregnancy) and was significantly associated with lupus activity and fetal loss during lupus pregnancy. The type I interferon signature of pregnant patients with SLE was negatively correlated with the level of IgG sialylation. The lack of sialylation dampened the ability of IgG to suppress the functions of plasmacytoid dendritic cells (pDCs). RNA-seq analysis further revealed that the expression of genes associated with the spleen tyrosine kinase (SYK) signaling pathway significantly differed between IgG- and deSia-IgG-treated pDCs. This finding was confirmed by the attenuation of the ability to phosphorylate SYK and BLNK in deSia-IgG. Finally, the coculture of pDCs isolated from pregnant patients with SLE with IgG/deSia-IgG demonstrated the sialylation-dependent anti-inflammatory function of IgG. Our findings suggested that IgG influences lupus activity through regulating pDCs function via the modulation of the SYK pathway in a sialic acid-dependent manner.

关键词： pregnancy IgG glycome type I interferon systemic lupus erythematosus